STYX and EPHA3

Data Source:
BioGRID (two hybrid)

		STYX	EPHA3
Description		serine/threonine/tyrosine interacting protein	EPH receptor A3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Nucleoplasm Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Nuclear Membrane Neuron Projection Receptor Complex
	Molecular Function	Pseudophosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity F-box Domain Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity MAPK Export From Nucleus Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Kinase Activity Regulation Of GTPase Activity Negative Regulation Of Endocytosis Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Protein Localization To Plasma Membrane
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Prostate cancer ( 23535732)	Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 26635082) Orofacial clefts ( 22863734) Periodontitis (Mean PAL) ( 24024966) Post-bronchodilator FEV1 x air pollution (NO2) interaction in childhood asthma ( 31028280) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Tea consumption ( 31046077) Thrombosis ( 26908601) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK	29 interacting genes: ABL1 ADAM10 CDKN2A CRK CTDSP2 DUSP18 DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 ERBB2 FBXO7 FYN ILKAP MTMR11 PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 STYX TP53 TPTE
Entrez ID		6815	2042
HPRD ID		10258	01555
Ensembl ID		ENSG00000198252	ENSG00000044524
Uniprot IDs		A0A024R641 Q8WUJ0	A0A140VJJ0 C9JXA2 P29320 Q6P4R6
PDB IDs		2R0B	2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4 4L0P 4P4C 4P5Q 4P5Z 4TWN 4TWO 6IN0
Enriched GO Terms of Interacting Partners?
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