STX5 and STING1

Data Source:
BioGRID (two hybrid)

		STX5	STING1
Description		syntaxin 5	stimulator of interferon response cGAMP interactor 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane SNARE Complex Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Autophagosome Membrane Nucleoplasm Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Perinuclear Region Of Cytoplasm Integral Component Of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Cadherin Binding Protein N-terminus Binding	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process COPII Vesicle Coating Vesicle Docking Vesicle Fusion With Golgi Apparatus Golgi Disassembly Regulation Of Golgi Organization	Autophagosome Assembly Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Viral Process Positive Regulation Of Macroautophagy Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Cellular Response To Interferon-beta Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Protein Complex Oligomerization Defense Response To Virus Reticulophagy Cellular Response To Exogenous DsRNA Cellular Response To Organic Cyclic Compound
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		52 interacting genes: AARD APLP1 AQP6 BAG6 BET1 CCDC153 COPS6 CRB3 CREB3L3 EBP FAM209A GET3 GOSR1 GOSR2 GPANK1 GPR152 HAP1 HSD17B11 HSD17B13 IMMT JAGN1 KASH5 LMNA LNX1 LRIF1 LRRC4C MAGEA6 MTUS1 NAPA NAPB NSFL1C REEP4 RETREG3 SCFD1 SEC22B SNAP23 SNAP25 STING1 STX1A STX2 STX3 STX4 STX8 STXBP1 TACC1 TMEM31 TP53 USO1 VAMP5 VAPB VCP VCPIP1	22 interacting genes: CCDC47 CMTM5 DDOST IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 PLLP REEP6 RNF26 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM32 USP20 USP49 YIPF2
Entrez ID		6811	340061
HPRD ID		04426	14173
Ensembl ID		ENSG00000162236	ENSG00000184584
Uniprot IDs		B4DKR0 Q13190	J3QTB1 Q86WV6 V5V0K2
PDB IDs		3EFO	4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6RM0 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XNP
Enriched GO Terms of Interacting Partners?
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