STING1 and MUL1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		STING1	MUL1
Description		stimulator of interferon response cGAMP interactor 1	mitochondrial E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Autophagosome Membrane Nucleoplasm Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Perinuclear Region Of Cytoplasm Integral Component Of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane	Mitochondrion Peroxisome Membrane Axon Integral Component Of Mitochondrial Outer Membrane Neuronal Cell Body
	Molecular Function	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Viral Process Positive Regulation Of Macroautophagy Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Cellular Response To Interferon-beta Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Protein Complex Oligomerization Defense Response To Virus Reticulophagy Cellular Response To Exogenous DsRNA Cellular Response To Organic Cyclic Compound	Protein Polyubiquitination Mitochondrial Fission Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation	Ub-specific processing proteases
Drugs
Diseases
GWAS			Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		22 interacting genes: CCDC47 CMTM5 DDOST IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 PLLP REEP6 RNF26 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM32 USP20 USP49 YIPF2	34 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 KRTAP10-8 MAP3K7 RANGAP1 REEP2 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W UBXN7 ULK1
Entrez ID		340061	79594
HPRD ID		14173	07799
Ensembl ID		ENSG00000184584	ENSG00000090432
Uniprot IDs		J3QTB1 Q86WV6 V5V0K2	A1PUM0 Q969V5
PDB IDs		4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6RM0 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XNP	6K2K
Enriched GO Terms of Interacting Partners?
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