SREBF1 and MED25

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SREBF1	MED25
Description		sterol regulatory element binding transcription factor 1	mediator complex subunit 25
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Nucleoplasm Transcription Regulator Complex Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Lipid Localization Regulation Of Lipid Storage Regulation Of Fatty Acid Metabolic Process Lung Development Intracellular Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone SREBP Signaling Pathway Response To Glucagon Response To Drug MRNA Transcription By RNA Polymerase II Fat Cell Differentiation Response To Ethanol Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		RORA activates gene expression FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Coffee consumption ( 31046077) Eosinophil counts ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Parkinson's disease ( 21738487) Resting heart rate ( 27798624) Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) White blood cell count ( 32888494)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		40 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP EP300 ESR1 ESR2 FBXW7 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C	37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2
Entrez ID		6720	81857
HPRD ID		01701	14380
Ensembl ID		ENSG00000072310	ENSG00000104973
Uniprot IDs		A8MTU8 B3KR77 P36956	Q71SY5
PDB IDs		1AM9	2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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