MED25 and STAT5B

Data Source:
BioGRID (two hybrid)

		MED25	STAT5B
Description		mediator complex subunit 25	signal transducer and activator of transcription 5B
Image
GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Mediator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding Identical Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly	Luteinization Natural Killer Cell Differentiation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Interleukin-2 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Population Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Interleukin-4 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Dasatinib
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Growth hormone insensitivity with immunodeficiency
GWAS		Blood trace element (Se levels) ( 23720494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 32296059) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 27569725 28067908 23128233) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908)
Interacting Genes		37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2	62 interacting genes: AFTPH APP CBL CD247 CDKN1A CENPJ CHAF1A CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 HNRNPA2B1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT LGALS14 LMO4 MAPK1 MED25 MRPS6 NCOR2 NMI NR3C1 PDGFRA PDGFRB PIK3R3 POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA RBBP4 SERTAD1 SHC1 SRC STAC STAP2 STAT1 STAT3 STAT5A SUOX TEK TFG TSSK3 USP2
Entrez ID		81857	6777
HPRD ID		14380	05037
Ensembl ID		ENSG00000104973	ENSG00000173757
Uniprot IDs		Q71SY5	P51692
PDB IDs		2KY6 2L23 2L6U 2XNF	6MBW 6MBZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?