MED25 and CTDP1

Data Source:
BioGRID (pull down)

		MED25	CTDP1
Description		mediator complex subunit 25	CTD phosphatase subunit 1
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GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Mediator Complex	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Midbody Protein-containing Complex Intracellular Membrane-bounded Organelle Spindle Midzone
	Molecular Function	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding	TFIIF-class Transcription Factor Complex Binding Phosphoprotein Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Tat Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Dephosphorylation Exit From Mitosis Positive Regulation By Host Of Viral Transcription Positive Regulation Of Viral Transcription Cell Division Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Dephosphorylation Of RNA Polymerase II C-terminal Domain
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood trace element (Se levels) ( 23720494)	Adverse response to drug ( 30420678) Cerebrospinal P-tau181p levels ( 28247064) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494) Schizophrenia ( 23212062) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2	40 interacting genes: CDK7 CDK8 CDK9 CSNK2A1 CSNK2A2 CSNK2B E2F1 ELP2 ELP3 ERH GTF2F1 INTS1 INTS3 INTS6 INTS7 INTS8 MED1 MED14 MED15 MED16 MED17 MED23 MED24 MED25 MED26 MED4 MED6 MED7 MED8 NDRG2 POLR2A POLR2B PRKDC PRMT5 SNRNP70 SNRPB STK38 TCEA1 UPP1 WDR77
Entrez ID		81857	9150
HPRD ID		14380	05377
Ensembl ID		ENSG00000104973	ENSG00000060069
Uniprot IDs		Q71SY5	A0A0A0MR03 Q9Y5B0
PDB IDs		2KY6 2L23 2L6U 2XNF	1J2X 1ONV 2K7L
Enriched GO Terms of Interacting Partners?
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