SOS2 and PACSIN3

Data Source:
HPRD (in vitro, in vivo)

		SOS2	PACSIN3
Description		SOS Ras/Rho guanine nucleotide exchange factor 2	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding
	Biological Process	B Cell Homeostasis G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Pro-B Cell Differentiation	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		16 interacting genes: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9	23 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL
Entrez ID		6655	29763
HPRD ID		03149	05937
Ensembl ID		ENSG00000100485	ENSG00000165912
Uniprot IDs		Q07890	Q9UKS6
PDB IDs		6EIE
Enriched GO Terms of Interacting Partners?
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