SOS2 and SH3D19

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SOS2	SH3D19
Description		SOS Ras/Rho guanine nucleotide exchange factor 2	SH3 domain containing 19
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	B Cell Homeostasis G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Pro-B Cell Differentiation	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		16 interacting genes: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9	12 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2
Entrez ID		6655	152503
HPRD ID		03149	16364
Ensembl ID		ENSG00000100485	ENSG00000109686
Uniprot IDs		Q07890	A0A494C1M0 Q5HYK7
PDB IDs		6EIE
Enriched GO Terms of Interacting Partners?
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