SNRPA and SMAD5

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SNRPA	SMAD5
Description		small nuclear ribonucleoprotein polypeptide A	SMAD family member 5
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GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U1 SnRNP	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	RNA Binding Protein Binding U1 SnRNA Binding Identical Protein Binding U1 SnRNP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of MRNA Polyadenylation	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		mRNA Splicing - Major Pathway	Signaling by BMP
Drugs		Malonic acid
Diseases
GWAS		Blood protein levels ( 28240269) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 27863252) melanoma-derived growth regulatory protein levels ( 25147954) Post bronchodilator FEV1 ( 26634245)	Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)
Interacting Genes		53 interacting genes: CDKN2A CHTOP CIRBP DAPK1 DAZAP1 DDIT4L DDX39B EEF1AKNMT ENOX2 FBXO7 FUBP1 GABPB1 GIGYF1 HNRNPK IL7R LENG8 LHX4 LNX1 MBNL2 MRPL15 MTUS2 NDUFAF3 OTX2 PAPOLA PCBP1 PCBP2 PCBP3 PTBP1 PTBP2 QKI RASAL3 RBM11 RBM3 RBM42 RBM4B RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 SDCBP SFPQ SMAD5 SNRPA1 TIAL1 TLE5 TNFAIP8L1 TRIM27 TRIR U2AF2 UBC WBP4 ZCCHC13	46 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8
Entrez ID		6626	4090
HPRD ID		01658	04381
Ensembl ID		ENSG00000077312	ENSG00000113658
Uniprot IDs		P09012	Q68DB7 Q99717
PDB IDs		1AUD 1DRZ 1DZ5 1FHT 1M5K 1M5O 1M5P 1M5V 1NU4 1OIA 1SJ3 1SJ4 1SJF 1U6B 1URN 1VBX 1VBY 1VBZ 1VC0 1VC5 1VC6 1ZZN 2A3J 2NZ4 2OIH 2OJ3 2U1A 3BO2 3BO3 3BO4 3CUL 3CUN 3EGZ 3G8S 3G8T 3G96 3G9C 3HHN 3IIN 3IRW 3IWN 3K0J 3L3C 3MUM 3MUR 3MUT 3MUV 3MXH 3P49 3PGW 3R1H 3R1L 3UCU 3UCZ 3UD3 3UD4 3UTR 4C4W 4PR6 4PRF 4W90 4W92 4YB1 5DDO 5DDP 5DDQ 5DDR 5FJ4 6LAS 6LAU 6LAX 6LAZ 6QX9 6SQN 6SQQ 6SQT 6SQV 6SR7	6FZS 6TCE
Enriched GO Terms of Interacting Partners?
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