SNRPA and PAPOLA

Data Source:
HPRD (in vitro)

		SNRPA	PAPOLA
Description		small nuclear ribonucleoprotein polypeptide A	poly(A) polymerase alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U1 SnRNP	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Protein Binding U1 SnRNA Binding Identical Protein Binding U1 SnRNP Binding	Magnesium Ion Binding RNA Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Manganese Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of MRNA Polyadenylation	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA 3'-end Processing Regulation Of MRNA 3'-end Processing RNA Polyadenylation
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs		Malonic acid	Cordycepin Triphosphate 3-sulfino-L-alanine Triphosphoric acid
Diseases
GWAS		Blood protein levels ( 28240269) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 27863252) melanoma-derived growth regulatory protein levels ( 25147954) Post bronchodilator FEV1 ( 26634245)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Copper levels ( 26025379) Metabolite levels ( 23823483) Number of stillbirths in continuous marriage ( 30188897)
Interacting Genes		53 interacting genes: CDKN2A CHTOP CIRBP DAPK1 DAZAP1 DDIT4L DDX39B EEF1AKNMT ENOX2 FBXO7 FUBP1 GABPB1 GIGYF1 HNRNPK IL7R LENG8 LHX4 LNX1 MBNL2 MRPL15 MTUS2 NDUFAF3 OTX2 PAPOLA PCBP1 PCBP2 PCBP3 PTBP1 PTBP2 QKI RASAL3 RBM11 RBM3 RBM42 RBM4B RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 SDCBP SFPQ SMAD5 SNRPA1 TIAL1 TLE5 TNFAIP8L1 TRIM27 TRIR U2AF2 UBC WBP4 ZCCHC13	6 interacting genes: CPSF1 CPSF3 FIP1L1 SMAD2 SNRPA YWHAE
Entrez ID		6626	10914
HPRD ID		01658	10407
Ensembl ID		ENSG00000077312	ENSG00000090060
Uniprot IDs		P09012	A0A024R6J7 A0A024R6M3 A0A0C4DGK1 P51003
PDB IDs		1AUD 1DRZ 1DZ5 1FHT 1M5K 1M5O 1M5P 1M5V 1NU4 1OIA 1SJ3 1SJ4 1SJF 1U6B 1URN 1VBX 1VBY 1VBZ 1VC0 1VC5 1VC6 1ZZN 2A3J 2NZ4 2OIH 2OJ3 2U1A 3BO2 3BO3 3BO4 3CUL 3CUN 3EGZ 3G8S 3G8T 3G96 3G9C 3HHN 3IIN 3IRW 3IWN 3K0J 3L3C 3MUM 3MUR 3MUT 3MUV 3MXH 3P49 3PGW 3R1H 3R1L 3UCU 3UCZ 3UD3 3UD4 3UTR 4C4W 4PR6 4PRF 4W90 4W92 4YB1 5DDO 5DDP 5DDQ 5DDR 5FJ4 6LAS 6LAU 6LAX 6LAZ 6QX9 6SQN 6SQQ 6SQT 6SQV 6SR7
Enriched GO Terms of Interacting Partners?
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