SMAD5 and HOXD13

Data Source:
HPRD (two hybrid)

		SMAD5	HOXD13
Description		SMAD family member 5	homeobox D13
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Chromatin Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding DEAD/H-box RNA Helicase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding I-SMAD Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Anatomical Structure Morphogenesis Embryonic Pattern Specification Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Skeletal System Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Anterior/posterior Pattern Specification Male Genitalia Development Response To Testosterone Regulation Of Cell Population Proliferation Embryonic Digit Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hindgut Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Morphogenesis Of An Epithelial Fold Branch Elongation Of An Epithelium Regulation Of Branching Involved In Prostate Gland Morphogenesis
Pathways		Signaling by BMP
Drugs
Diseases			Brachydactyly, including: type A; type B; type D; type E Syndactyly Brachydactyly-syndactyly syndrome Synpolydactyly
GWAS		Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean platelet volume ( 32888494) Sleep duration (short sleep) ( 30846698)	Male-pattern baldness ( 28196072)
Interacting Genes		46 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP POU6F2 PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WBP2 WWP1 ZEB2 ZNF8	5 interacting genes: CREBBP MEIS1 SMAD1 SMAD2 SMAD5
Entrez ID		4090	3239
HPRD ID		04381	00872
Ensembl ID		ENSG00000113658	ENSG00000128714
Uniprot IDs		Q68DB7 Q99717	P35453
PDB IDs		6FZS 6TCE
Enriched GO Terms of Interacting Partners?
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