SLC34A1 and PDZK1

Data Source:
BioGRID (two hybrid, pull down)

		SLC34A1	PDZK1
Description		solute carrier family 34 member 1	PDZ domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Brush Border Cell Surface Apical Plasma Membrane Nuclear Speck Brush Border Membrane Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Mitotic Spindle	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Sodium:phosphate Symporter Activity Protein Binding PDZ Domain Binding Identical Protein Binding Protein-containing Complex Binding	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding
	Biological Process	Ossification Kidney Development Phosphate Ion Transport Glycoprotein Metabolic Process Response To Lead Ion Cellular Phosphate Ion Homeostasis Response To Magnesium Ion Response To Estradiol Response To Vitamin A Phosphate Ion Transmembrane Transport Response To Potassium Ion Indole Metabolic Process Response To Drug Cellular Protein Metabolic Process Sodium-dependent Phosphate Transport Positive Regulation Of Membrane Potential Response To Cadmium Ion Response To Mercury Ion Phosphate Ion Homeostasis Response To Growth Hormone Cellular Response To Metal Ion Cellular Response To Parathyroid Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Staurosporine Response To Thyroid Hormone Dentinogenesis Sodium Ion Import Across Plasma Membrane Gentamycin Metabolic Process Arsenate Ion Transmembrane Transport Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Phosphate Transmembrane Transport	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Type II Na+/Pi cotransporters Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) Surfactant metabolism
Drugs
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Activated partial thromboplastin time ( 22703881) Asthma ( 32296059) Calcium levels ( 24068962) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462 28270201 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hematocrit ( 29403010) Inflammatory bowel disease ( 28067908) Kidney stones ( 26272126 31729369) Nephrolithiasis ( 22396660) Phosphorus levels ( 29403010) Red blood cell count ( 29403010) Serum parathyroid hormone levels ( 27927781) Ulcerative colitis ( 28067908) Urinary electrolytes (magnesium/calcium ratio) ( 27915449) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Contrast sensitivity ( 24152035) Gout ( 32238385) Serum uric acid levels ( 30993211) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)
Interacting Genes		11 interacting genes: BSPRY FHL2 HPCAL1 HSP90AA1 HSP90AB1 MAST2 PDZK1 PEX19 SLC9A3R1 SLC9A3R2 YIF1A	31 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		6569	5174
HPRD ID		08918	04829
Ensembl ID		ENSG00000131183	ENSG00000174827
Uniprot IDs		A0A024R7R9 Q06495 Q7Z725 Q86VN6	Q5T2W1
PDB IDs			2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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