PDZK1 and GFAP

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDZK1	GFAP
Description		PDZ domain containing 1	glial fibrillary acidic protein
Image
GO Annotations	Cellular Component	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome	Cytoplasm Lysosome Cytosol Intermediate Filament Intermediate Filament Cytoskeleton
	Molecular Function	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding
	Biological Process	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Regulation Of Protein-containing Complex Assembly Intermediate Filament Organization Regulation Of Chaperone-mediated Autophagy
Pathways			Nuclear signaling by ERBB4 Chaperone Mediated Autophagy
Drugs
Diseases			Alexander disease
GWAS		Contrast sensitivity ( 24152035) Gout ( 32238385) Serum uric acid levels ( 30993211) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)
Interacting Genes		31 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	80 interacting genes: ABI2 AKT1 APP AURKB BIRC2 CAMK2A CARD10 CCDC57 CDC37 CDK1 CEP76 CFAP206 CRYAB CT55 CWF19L2 DES ENKD1 EPM2AIP1 FAM50B GOLGA2 GRAP2 HGS HOMEZ IKBKG KIAA0408 KRT13 KRT15 KRT19 KRT27 KRT31 KRT39 LENG1 LGALS14 LMO2 MAPK9 MEN1 MOS MYBPHL MYO15B NEFL NEK6 NFKBID NTAQ1 NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PPP1R16B PPP1R18 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCB1 SRC STAT1 TBC1D21 TBC1D22B TFIP11 TLE5 TP53BP2 TRIM27 TUBGCP4 UBASH3A UBE3A VIM YES1 ZC2HC1C ZNF655 ZNF774
Entrez ID		5174	2670
HPRD ID		04829	00675
Ensembl ID		ENSG00000174827	ENSG00000131095
Uniprot IDs		Q5T2W1	A7REI1 P14136
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI	6A9P
Enriched GO Terms of Interacting Partners?
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