SIPA1 and COP1

Data Source:
HPRD (two hybrid, in vitro)

		SIPA1	COP1
Description		signal-induced proliferation-associated 1	COP1 E3 ubiquitin ligase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Transport Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	GTPase Activator Activity Protein Binding Protein C-terminus Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Negative Regulation Of Cell Growth Intracellular Signal Transduction Cellular Response To Water Deprivation Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		Rap1 signalling	Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31619474) Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) HDL cholesterol ( 30275531) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet count ( 27863252) Pulse pressure ( 30578418) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27841878 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		3 interacting genes: CDKN1A COP1 DVL1	19 interacting genes: CCT4 CDKN1B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ
Entrez ID		6494	64326
HPRD ID		03713	07455
Ensembl ID		ENSG00000213445	ENSG00000143207
Uniprot IDs		Q96FS4	Q8NHY2 X5D7N8 X5DNY7
PDB IDs			5HQG 5IGQ
Enriched GO Terms of Interacting Partners?
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