COP1 and STK40

Data Source:
BioGRID (unspecified method)

		COP1	STK40
Description		COP1 E3 ubiquitin ligase	serine/threonine kinase 40
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Respiratory System Process Glycogen Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
Drugs
Diseases
GWAS			Neutrophil count ( 32888494)
Interacting Genes		19 interacting genes: CCT4 CDKN1B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ	7 interacting genes: APP COP1 COPS6 LRRK2 NEDD4L POLA2 SLIRP
Entrez ID		64326	83931
HPRD ID		07455	11359
Ensembl ID		ENSG00000143207	ENSG00000196182
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	Q8N2I9
PDB IDs		5HQG 5IGQ	5L2Q
Enriched GO Terms of Interacting Partners?
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