PORCN and WNT5B

Data Source:
HPRD (in vivo, in vitro)

		PORCN	WNT5B
Description		porcupine O-acyltransferase	Wnt family member 5B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Transferase Activity, Transferring Acyl Groups Wnt-protein Binding Palmitoleoyltransferase Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity
	Biological Process	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Protein Palmitoylation Lipid Modification Protein Palmitoleylation Canonical Wnt Signaling Pathway Wnt Protein Secretion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Chondrocyte Differentiation Wnt Signaling Pathway Neuron Differentiation Positive Regulation Of Cell Migration Wound Healing Muscle Cell Differentiation Cell Fate Commitment Fat Cell Differentiation Canonical Wnt Signaling Pathway Lens Fiber Cell Development Cellular Response To Retinoic Acid Positive Regulation Of Convergent Extension Involved In Gastrulation Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		WNT ligand biogenesis and trafficking LGK974 inhibits PORCN	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking PCP/CE pathway PCP/CE pathway
Drugs
Diseases		Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gout ( 22179738) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		9 interacting genes: APOC2 APOC4 CBARP WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	2 interacting genes: APPBP2 PORCN
Entrez ID		64840	81029
HPRD ID		06680	05899
Ensembl ID		ENSG00000102312	ENSG00000111186
Uniprot IDs		Q9H237	Q9H1J7
PDB IDs
Enriched GO Terms of Interacting Partners?
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