PORCN and WNT6

Data Source:
HPRD (in vitro, in vivo)

		PORCN	WNT6
Description		porcupine O-acyltransferase	Wnt family member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Transferase Activity, Transferring Acyl Groups Wnt-protein Binding Palmitoleoyltransferase Activity	Frizzled Binding Cytokine Activity
	Biological Process	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Protein Palmitoylation Lipid Modification Protein Palmitoleylation Canonical Wnt Signaling Pathway Wnt Protein Secretion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Branching Involved In Ureteric Bud Morphogenesis Axis Specification Positive Regulation Of Gene Expression Wnt Signaling Pathway Neuron Differentiation Odontogenesis Of Dentin-containing Tooth Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Epithelial-mesenchymal Cell Signaling Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Retinoic Acid Nephron Tubule Formation
Pathways		WNT ligand biogenesis and trafficking LGK974 inhibits PORCN	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases		Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS			Height ( 31562340) Male-pattern baldness ( 28196072) Reticulocyte count ( 32888494)
Interacting Genes		9 interacting genes: APOC2 APOC4 CBARP WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B	2 interacting genes: PORCN RHOU
Entrez ID		64840	7475
HPRD ID		06680	05233
Ensembl ID		ENSG00000102312	ENSG00000115596
Uniprot IDs		Q9H237	Q8N2E5 Q9Y6F9
PDB IDs
Enriched GO Terms of Interacting Partners?
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