SH3GL3 and SNRPN

Data Source:
HPRD (two hybrid)

		SH3GL3	SNRPN
Description		SH3 domain containing GRB2 like 3, endophilin A3	small nuclear ribonucleoprotein polypeptide N
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GO Annotations	Cellular Component	Acrosomal Vesicle Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleoplasm Spliceosomal Complex U5 SnRNP U1 SnRNP U2 SnRNP U4 SnRNP Cytoplasm Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis	MRNA Splicing, Via Spliceosome RNA Splicing Response To Hormone
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription	mRNA Splicing - Major Pathway
Drugs
Diseases			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 28552196 25282103 18391950 18391951 20397748) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Spine bone size ( 31053729) Working memory ( 31598132)	Aspartate aminotransferase levels ( 31219225) Carotid plaque burden ( 28282560) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Obesity-related traits ( 23251661) Panic disorder ( 31712720) Periodontal disease related phenotype (PCT5) ( 26962152) Periodontitis (DPAL) ( 24024966) Pulmonary function ( 17903307)
Interacting Genes		51 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33	11 interacting genes: ARL4D CTBP1 FBL GEMIN2 GTF2I KEAP1 LRIF1 MAFG RBFOX1 SH3GL3 TP53
Entrez ID		6457	6638
HPRD ID		04528	01653
Ensembl ID		ENSG00000140600	ENSG00000128739
Uniprot IDs		A0A024R215 Q99963	P63162 X5DP00
PDB IDs		2EW3 2Z0V	5MF9
Enriched GO Terms of Interacting Partners?
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