SH3GL3 and ATXN2

Data Source:
BioGRID (pull down, pull down, imaging technique)
HPRD (two hybrid, in vivo)

		SH3GL3	ATXN2
Description		SH3 domain containing GRB2 like 3, endophilin A3	ataxin 2
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Polysome Cytoplasmic Stress Granule Membrane Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Identical Protein Binding	RNA Binding Epidermal Growth Factor Receptor Binding Protein Binding Protein C-terminus Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis	Negative Regulation Of Receptor Internalization Regulation Of Translation Regulation Of Cytoplasmic MRNA Processing Body Assembly RNA Metabolic Process P-body Assembly Stress Granule Assembly RNA Transport
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 28552196 25282103 18391950 18391951 20397748) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Spine bone size ( 31053729) Working memory ( 31598132)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Alopecia areata ( 25608926) Apolipoprotein B levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 30929738 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Beta-2 microglubulin plasma levels ( 23417110) Blood osmolality (transformed sodium) ( 28360221) Blood pressure ( 21909110) Body mass index ( 26426971) Celiac disease ( 22057235 18311140) Chronic kidney disease ( 20383146) Coronary artery disease ( 29212778 30104761) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 27736895 19430483) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Gastroesophageal reflux disease ( 31527586) Glaucoma (primary open-angle) ( 26752265) Glomerular filtration rate (cystatin C) ( 28452372) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) Heart failure ( 31919418) Hematocrit ( 19862010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 30054594) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricle diastolic internal dimension ( 28394258) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 24026423 29403010 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Reaction time ( 29844566) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Reticulocyte fraction of red cells ( 27863252) Retinal vascular caliber ( 21060863) Sarcoidosis ( 26051272) Serum total protein level ( 29403010) SjÃ¶gren's syndrome ( 24097067) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Total cholesterol levels ( 30275531) Urate levels ( 31578528 23263486) Vitiligo ( 27723757) White blood cell count ( 32888494)
Interacting Genes		51 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33	22 interacting genes: ACTN1 ACTN2 ATXN1 BAG6 BIN1 CHGB GFI1B GOLGA6L5P IDH3B KIFBP LCP1 MIR128-1 MIR34B MIR7-1 NCOA4 PABPC1 PLS3 POLR1H RBFOX1 SH3GL2 SH3GL3 TDRD7
Entrez ID		6457	6311
HPRD ID		04528	03307
Ensembl ID		ENSG00000140600	ENSG00000204842
Uniprot IDs		A0A024R215 Q99963	F8VQP2 Q2M2R5 Q99700
PDB IDs		2EW3 2Z0V	3KTR
Enriched GO Terms of Interacting Partners?
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