SH3GL3 and PDCD6IP

Data Source:
HPRD (in vivo, two hybrid)

		SH3GL3	PDCD6IP
Description		SH3 domain containing GRB2 like 3, endophilin A3	programmed cell death 6 interacting protein
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GO Annotations	Cellular Component	Acrosomal Vesicle Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Immunological Synapse Microtubule Organizing Center Cytosol Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Identical Protein Binding	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Life Cycle Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription	Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 28552196 25282103 18391950 18391951 20397748) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Spine bone size ( 31053729) Working memory ( 31598132)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		51 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33	36 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 DRD1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 MAPK6 PDCD6 PTK2B RAMP3 RNF11 SDCBP SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SRC SUMO2 TAB1 TSG101 TTF2 UBC VPS28 VPS37C YES1
Entrez ID		6457	10015
HPRD ID		04528	06425
Ensembl ID		ENSG00000140600	ENSG00000170248
Uniprot IDs		A0A024R215 Q99963	Q8WUM4
PDB IDs		2EW3 2Z0V	2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1 6KP3
Enriched GO Terms of Interacting Partners?
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