SH3GL1 and RHEX

Data Source:
BioGRID (two hybrid)

		SH3GL1	RHEX
Description		SH3 domain containing GRB2 like 1, endophilin A2	regulator of hemoglobinization and erythroid cell expansion
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Early Endosome Membrane Cell Projection Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding SH3 Domain Binding Phosphatase Binding Beta-1 Adrenergic Receptor Binding Identical Protein Binding Ion Channel Binding Cadherin Binding GTPase Binding	Erythropoietin Receptor Binding Protein Binding
	Biological Process	Signal Transduction Central Nervous System Development Synaptic Vesicle Uncoating Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Endocytosis	Cellular Response To Erythropoietin Erythropoietin-mediated Signaling Pathway Erythrocyte Maturation Positive Regulation Of Erythrocyte Differentiation
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		37 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PRR5-ARHGAP8 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VIM VPS37C YWHAZ	7 interacting genes: GAD2 GET3 PBX3 RBFA SH3GL1 SH3GLB1 SNX1
Entrez ID		6455	440712
HPRD ID		03462	17400
Ensembl ID		ENSG00000141985	ENSG00000263961
Uniprot IDs		Q6FGM0 Q99961	Q6ZWK4
PDB IDs
Enriched GO Terms of Interacting Partners?
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