SH3GL1 and ARHGAP8

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vitro, in vivo)

		SH3GL1	ARHGAP8
Description		SH3 domain containing GRB2 like 1, endophilin A2	Rho GTPase activating protein 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Early Endosome Membrane Cell Projection Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Cytosol
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding SH3 Domain Binding Phosphatase Binding Beta-1 Adrenergic Receptor Binding Identical Protein Binding Ion Channel Binding Cadherin Binding GTPase Binding	GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Central Nervous System Development Synaptic Vesicle Uncoating Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Endocytosis	Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Rho GTPase cycle
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Red cell distribution width ( 32888494)	Binge eating behaviour in bipolar disorder ( 29391396) Body mass index ( 28552196) Electroencephalographic traits in alcoholism ( 22554406) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Weight ( 28552196)
Interacting Genes		37 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PRR5-ARHGAP8 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VIM VPS37C YWHAZ	6 interacting genes: BNIP2 CTTN CYGB RHOA SH3GL1 ZMYND12
Entrez ID		6455	23779
HPRD ID		03462	06448
Ensembl ID		ENSG00000141985	ENSG00000241484
Uniprot IDs		Q6FGM0 Q99961	P85298 Q6PJW1
PDB IDs
Enriched GO Terms of Interacting Partners?
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