SGCG and SSPN

Data Source:
HPRD (in vivo, in vitro)

		SGCG	SSPN
Description		sarcoglycan gamma	sarcospan
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Sarcoglycan Complex Integral Component Of Membrane Sarcolemma	Integral Component Of Plasma Membrane Dystrophin-associated Glycoprotein Complex Transport Vesicle Sarcolemma Postsynaptic Membrane
	Molecular Function	Protein Binding
	Biological Process	Muscle Organ Development Cardiac Muscle Tissue Development Heart Contraction	Muscle Contraction Cell Adhesion
Pathways
Drugs
Diseases		Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F Limb-girdle muscular dystrophy (LGMD)
GWAS		Alanine aminotransferase levels ( 31219225) Asthma ( 27611488) Atrial fibrillation ( 30061737) Bipolar disorder ( 21738484) Central corneal thickness ( 29760442) Corneal structure ( 23291589) Number of alcoholic drinks required to feel an effect (first five times drinking) ( 31270906) Type 2 diabetes ( 23300278)	Atrial fibrillation ( 30061737 29892015) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Monocyte count ( 32888494) PR interval ( 32439900) Triglyceride levels ( 32203549) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: APP CCT6A CLDN5 DNAJB6 DYSF ENO1 ENO3 FLNC HSPA1B MYBPC1 MYBPC2 MYLPF PSAP PYGM SGCB SGCD SPACA1 SSPN SUCLG2 TTN	2 interacting genes: SGCG SMO
Entrez ID		6445	8082
HPRD ID		07039	03359
Ensembl ID		ENSG00000102683	ENSG00000123096
Uniprot IDs		Q13326	Q14714
PDB IDs
Enriched GO Terms of Interacting Partners?
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