SGCA and TUBG1

Data Source:
BioGRID (affinity chromatography technology)

		SGCA	TUBG1
Description		sarcoglycan alpha	tubulin gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cell-cell Junction Dystrophin-associated Glycoprotein Complex Sarcoglycan Complex Integral Component Of Membrane Sarcolemma Membrane Raft	Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Spindle Polar Microtubule Cytosol Microtubule Recycling Endosome Mitotic Spindle Microtubule
	Molecular Function	Calcium Ion Binding Protein Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding
	Biological Process	Muscle Contraction Muscle Organ Development Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Tissue Regeneration	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Mitotic Spindle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Microtubule Organization Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Vinblastine
Diseases		Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F Limb-girdle muscular dystrophy (LGMD)
GWAS		Heel bone mineral density ( 30598549) Temporomandibular joint disorder ( 28081371) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		8 interacting genes: FN1 FSTL1 ITGB1BP2 SGCB SGCD SGTA SGTB TAF1	28 interacting genes: APP BRCA1 CENPJ CNTN2 CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4
Entrez ID		6442	7283
HPRD ID		02525	01853
Ensembl ID		ENSG00000108823	ENSG00000131462
Uniprot IDs		A0A0S2Z4P8 A0A0S2Z4Q1 Q16586	P23258
PDB IDs			1Z5V 1Z5W 3CB2 6V5V 6V6S
Enriched GO Terms of Interacting Partners?
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