SRSF3 and CLK2

Data Source:
BioGRID (two hybrid)

		SRSF3	CLK2
Description		serine and arginine rich splicing factor 3	CDC like kinase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Nuclear Body Nuclear Speck
	Molecular Function	RNA Binding Protein Binding Phospholipase Binding Sequence-specific MRNA Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Leukemia Inhibitory Factor	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs			Fostamatinib
Diseases
GWAS		Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		39 interacting genes: APP CHD1 CIRBP CLK1 CLK2 CLK3 CNNM3 DUX4 EXOSC6 GEMIN2 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMX RBMY1A1 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF1L5 U2AF2 YWHAB YWHAG YWHAQ	53 interacting genes: AKT1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUZP4 MRPL4 NXF1 PRM1 PRPF38A PTPN1 RBM39 RNF8 RNPS1 RSRP1 SDCBP SNIP1 SNRNP70 SRPK2 SRRM1 SRSF3 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21
Entrez ID		6428	1196
HPRD ID		04530	04289
Ensembl ID		ENSG00000112081	ENSG00000176444
Uniprot IDs		B2R6F3 P84103	A8K7I0 B7Z8N6 P49760
PDB IDs		2I2Y 2I38	3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?
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