CDH23 and MYO7A

Data Source:
HPRD (in vitro)

		CDH23	MYO7A
Description		cadherin related 23	myosin VIIA
Image
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane Catenin Complex Stereocilium	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Microvillus Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Myosin VII Complex Vesicle Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse Stereocilium Base Upper Tip-link Density
	Molecular Function	Calcium Ion Binding Protein Binding Cadherin Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Actin-dependent ATPase Activity Identical Protein Binding ADP Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Sensory Perception Of Sound Locomotory Behavior Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Photoreceptor Cell Maintenance Response To Stimulus Sensory Perception Of Light Stimulus Equilibrioception Regulation Of Cytosolic Calcium Ion Concentration Inner Ear Receptor Cell Stereocilium Organization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Phagolysosome Assembly Intracellular Protein Transport Actin Filament Organization Lysosome Organization Sensory Organ Development Visual Perception Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament Cellular Protein Localization Eye Photoreceptor Cell Development Mechanoreceptor Differentiation Post-embryonic Animal Organ Morphogenesis Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization
Pathways			The canonical retinoid cycle in rods (twilight vision)
Drugs
Diseases		Usher syndrome (US) Deafness, autosomal recessive	Usher syndrome (US) Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Bipolar disorder (body mass index interaction) ( 24322204) Blood protein levels ( 29875488) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cognitive performance (processing speed) ( 31598132) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Kidney function decline traits ( 25493955) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494) Progranulin levels ( 29186428) Selective IgA deficiency ( 27723758) Self-reported risk-taking behaviour ( 30271922) Systemic lupus erythematosus ( 33536424) Vitiligo ( 22951725)	Lewy body disease ( 25188341) Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)
Interacting Genes		3 interacting genes: CLK1 MYO7A USH1C	12 interacting genes: ACTA1 CALM1 CDH23 KEAP1 KHDRBS1 LINC00839 MAP2 MYRIP PRKAR1A USH1C VEZT WHRN
Entrez ID		64072	4647
HPRD ID		05699	02043
Ensembl ID		ENSG00000107736	ENSG00000137474
Uniprot IDs		A0A087WYR8 A5D6V9 Q6P152 Q8N5B3 Q9H251	Q13402
PDB IDs		2KBR 2KBS 2LSR 5TFM 5VVM 5WJ8	5MV9
Enriched GO Terms of Interacting Partners?
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