SELPLG and MVK

Data Source:
HPRD (in vivo)

		SELPLG	MVK
Description		selectin P ligand	mevalonate kinase
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GO Annotations	Cellular Component	Uropod Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Plasma Membrane Raft	Peroxisome Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Protein Binding	Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Cell Adhesion Hemopoiesis Viral Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Inflammatory Response
Pathways		Cell surface interactions at the vascular wall	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			Farnesyl thiopyrophosphate
Diseases			Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Conduct disorder (symptom count) ( 20585324)	Aspartate aminotransferase levels ( 29403010) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 24097068 18193043 20864672 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414)
Interacting Genes		14 interacting genes: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN	4 interacting genes: EWSR1 POT1 RNF141 TERF1
Entrez ID		6404	4598
HPRD ID		02845	02015
Ensembl ID		ENSG00000110876	ENSG00000110921
Uniprot IDs		Q14242	B2RDU6 B7Z301 F5H8H2 Q03426
PDB IDs		1G1S	2R3V
Enriched GO Terms of Interacting Partners?
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