SNX27 and DGKZ

Data Source:
HPRD (in vivo, two hybrid)

		SNX27	DGKZ
Description		sorting nexin 27	diacylglycerol kinase zeta
Image
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Endosome Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Nuclear Speck Lamellipodium Glutamatergic Synapse
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding
	Biological Process	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane	Phosphatidic Acid Biosynthetic Process Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Cell Migration Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity
Pathways			Effects of PIP2 hydrolysis
Drugs			alpha-Tocopherol succinate
Diseases
GWAS		Body mass index ( 26426971)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 28991256 29483656)
Interacting Genes		9 interacting genes: AKT2 APP DGKZ HLCS PNPLA3 PTEN RPS6KA1 SELP SUMO2	19 interacting genes: DMD HRAS LEPR MAPK6 PLCG1 POLR2M PRKCA RASGRP1 RB1 RBL1 RBL2 SAT1 SNTA1 SNTB1 SNTB2 SNTG1 SNX27 SRC TP53
Entrez ID		81609	8525
HPRD ID		11591	03260
Ensembl ID		ENSG00000143376	ENSG00000149091
Uniprot IDs		A0A2R8Y8A7 Q96L92	Q13574
PDB IDs		4HAS 5ZN9 6SAK	5ELQ
Enriched GO Terms of Interacting Partners?
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