EEF2K and RPS6KB2

Data Source:
HPRD (in vitro)

		EEF2K	RPS6KB2
Description		eukaryotic elongation factor 2 kinase	ribosomal protein S6 kinase B2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity ATP Binding Peptide Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Response To Ischemia Translational Elongation Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin	Translation Signal Transduction Peptidyl-serine Phosphorylation TOR Signaling Protein Kinase B Signaling Positive Regulation Of Translational Initiation
Pathways		mTORC1-mediated signalling	AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2	22 interacting genes: BTK COASY CSNK2B EEF2K EP300 FBXO25 FYN HNRNPA1 IKBKG KAT2B LRRK2 LYN MAPK8IP2 MTOR NEDD4L PDGFRB PDPK1 PRKCE RPS6 SRC SRPK1 SYK
Entrez ID		29904	6199
HPRD ID		07369	10203
Ensembl ID		ENSG00000103319	ENSG00000175634
Uniprot IDs		O00418	Q9UBS0
PDB IDs		5J8H 5KS5 6NX4
Enriched GO Terms of Interacting Partners?
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