RPN1 and SIGIRR

Data Source:
HPRD (two hybrid)

		RPN1	SIGIRR
Description		ribophorin I	single Ig and TIR domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Melanosome	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding	Protein Binding
	Biological Process	Cellular Protein Modification Process Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Cytokine Stimulus
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil counts ( 29403010 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mild to moderate chronic kidney disease ( 31178898) Monocyte count ( 23314186 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494 21738480) White blood cell count (basophil) ( 29403010)	Apolipoprotein A1 levels ( 32203549) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		17 interacting genes: ADRM1 CAMLG DPF1 DUX4 ERBB3 HSPA5 KRTAP1-3 RAD23A RBBP4 SGTA SIGIRR SMARCB1 UBC UBQLN1 UBQLN2 UBQLN4 WSB2	9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6
Entrez ID		6184	59307
HPRD ID		01598	12018
Ensembl ID		ENSG00000163902	ENSG00000185187
Uniprot IDs		P04843	C9JFX4 Q6IA17
PDB IDs		6S7O 6S7T
Enriched GO Terms of Interacting Partners?
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