SIGIRR

Description		single Ig and TIR domain containing
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Cytokine Stimulus
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6
Entrez ID		59307
HPRD ID		12018
Ensembl ID		ENSG00000185187
Uniprot IDs		C9JFX4 Q6IA17
PDB IDs
Enriched GO Terms of Interacting Partners?
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