SIGIRR and TLR5

Data Source:
HPRD (in vivo)

		SIGIRR	TLR5
Description		single Ig and TIR domain containing	toll like receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Cytokine Stimulus	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Defense Response To Bacterium Innate Immune Response Cellular Response To Mechanical Stimulus
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling	Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases			Systemic lupus erythematosus
GWAS		Apolipoprotein A1 levels ( 32203549) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	5 interacting genes: MYD88 RNF216 SIGIRR TLR1 TLR4
Entrez ID		59307	7100
HPRD ID		12018	04326
Ensembl ID		ENSG00000185187	ENSG00000187554
Uniprot IDs		C9JFX4 Q6IA17	A0A2R8Y7Z4 O60602
PDB IDs			1P95 3J0A
Enriched GO Terms of Interacting Partners?
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