EXOC4 and ING1

Data Source:
BioGRID (two hybrid)

		EXOC4	ING1
Description		exocyst complex component 4	inhibitor of growth family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Plasma Membrane Microvillus Membrane Growth Cone Membrane Myelin Sheath Abaxonal Region Synapse Flemming Body	Nucleus
	Molecular Function	Protein Binding PDZ Domain Binding Small GTPase Binding Protein N-terminus Binding	Protein Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Protein Targeting To Membrane Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Chemical Synaptic Transmission Regulation Of Macroautophagy Paraxial Mesoderm Formation Vesicle Tethering Involved In Exocytosis	Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Cell Death Negative Regulation Of Cell Growth Positive Regulation Of Transcription, DNA-templated
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Food allergy ( 29030101) Fruit consumption ( 32066663) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Moderate to vigorous physical activity levels ( 29899525) Mood instability ( 31168069) Peanut allergy ( 29030101) Plasma anti-thyroid peroxidase levels ( 29678681) QT interval ( 29213071) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Subcortical volume (MOSTest) ( 32665545) Tonometry ( 17903302) Vigorous physical activity ( 29899525)	Blood protein levels ( 30072576) Erosive tooth wear (severe vs non-severe) ( 29898447)
Interacting Genes		14 interacting genes: BIRC6 CCHCR1 CEP63 DISC1 DLG3 DLG4 DLGAP4 EXOC7 GOLGA1 GRIN2B ING1 MBD3 RALA SMARCE1	29 interacting genes: BRMS1 BRMS1L COPS2 CYTOR DMAP1 EP300 ESR1 EXOC4 H3C14 HDAC1 HDAC2 KAT2B MRGBP NQO1 PCNA RBBP4 RBBP7 RBP1 SAP30 SFN SIN3A TP53 UBC YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		60412	3621
HPRD ID		12185	03337
Ensembl ID		ENSG00000131558	ENSG00000153487
Uniprot IDs		Q6NX51 Q96A65	A0A0C4DFW2 Q9UK53
PDB IDs			2QIC
Enriched GO Terms of Interacting Partners?
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