SENP2 and FUNDC1

Data Source:
BioGRID (two hybrid)

		SENP2	FUNDC1
Description		SUMO specific peptidase 2	FUN14 domain containing 1
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytosol PML Body Nuclear Membrane	Mitochondrial Outer Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding SUMO-specific Endopeptidase Activity SUMO-specific Isopeptidase Activity	Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	Autophagy Of Mitochondrion Response To Hypoxia Response To Organonitrogen Compound Macroautophagy
Pathways		SUMO is proteolytically processed	Receptor Mediated Mitophagy
Drugs
Diseases
GWAS		Diastolic blood pressure ( 28135244 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 27841878 26969751)	Facial morphology (factor 22) ( 28441456) Personality dimensions ( 18957941)
Interacting Genes		38 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63	15 interacting genes: CTBP1 CTBP2 EHHADH GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MARCHF5 MTERF3 SENP2 SH3GLB1 SLC25A46 SNX1 TUFM YES1
Entrez ID		59343	139341
HPRD ID		07002	06658
Ensembl ID		ENSG00000163904	ENSG00000069509
Uniprot IDs		Q9HC62	Q8IVP5
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK	2N9X 5GMV
Enriched GO Terms of Interacting Partners?
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