RAP2A and PLG

Data Source:
BioGRID (two hybrid)

		RAP2A	PLG
Description		RAP2A, member of RAS oncogene family	plasminogen
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding Kinase Binding Protein Domain Specific Binding Apolipoprotein Binding Chaperone Binding Protein Antigen Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Platelet Degranulation Proteolysis Blood Coagulation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Fibrinolysis Cellular Protein Metabolic Process Tissue Remodeling Biological Process Involved In Interaction With Symbiont Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Dissolution of Fibrin Clot
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate	Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic acid Aminocaproic acid Bicine Desmoteplase Aprotinin Copper Gabexate
Diseases			Inherited thrombophilia
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Aging ( 22773346) Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Childhood ear infection ( 27182965 28928442) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) End stage renal disease x APOL1 genotype interaction ( 29885931) Giant cell arteritis ( 28041642) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lp (a) levels ( 21900290) Myocardial infarction ( 26343387) Plasma plasminogen levels ( 25208887) Platelet count ( 32888494) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	60 interacting genes: ACTB AMOT ANXA2 APOH ATP5F1B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1
Entrez ID		5911	5340
HPRD ID		01547	01417
Ensembl ID		ENSG00000125249	ENSG00000122194
Uniprot IDs		P10114	P00747 Q5TEH5
PDB IDs		1KAO 2RAP 3RAP	1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4CIK 4DCB 4DUR 4DUU 5HPG 5UGD 5UGG 6D3X 6D3Y 6D3Z 6D40 6OG4 6OQJ 6OQK 6Q1U
Enriched GO Terms of Interacting Partners?
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