RAP1GAP and SDHB

Data Source:
BioGRID (affinity chromatography technology)

		RAP1GAP	SDHB
Description		RAP1 GTPase activating protein	succinate dehydrogenase complex iron sulfur subunit B
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex II, Succinate Dehydrogenase Complex (ubiquinone) Plasma Membrane Mitochondrial Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Protein Binding Succinate Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding Ubiquinone Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Signal Transduction Axon Guidance Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly	Tricarboxylic Acid Cycle Succinate Metabolic Process Aerobic Respiration Respiratory Electron Transport Chain
Pathways		Rap1 signalling RET signaling	Respiratory electron transport Citric acid cycle (TCA cycle)
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20189936) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		15 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12	6 interacting genes: ABCA1 CARTPT GEM PIK3R5 SPRY2 XRN1
Entrez ID		5909	6390
HPRD ID		02609	01707
Ensembl ID		ENSG00000076864	ENSG00000117118
Uniprot IDs		A0A024RAB5 P47736 X6R8W7	P21912
PDB IDs		1SRQ 3BRW
Enriched GO Terms of Interacting Partners?
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