CNKSR1 and TCAF1

Data Source:
BioGRID (two hybrid)

		CNKSR1	TCAF1
Description		connector enhancer of kinase suppressor of Ras 1	TRPM8 channel associated factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Plasma Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Ion Channel Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Regulation Of Anion Channel Activity Negative Regulation Of Cell Migration Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Anion Channel Activity
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	37 interacting genes: BIRC2 CAMK2A CEP70 CNKSR1 COIL CYSRT1 DISC1 EFEMP2 IKZF3 IKZF4 KRTAP1-3 KRTAP10-8 KRTAP13-2 KRTAP6-3 MAD1L1 MID2 NBPF19 NFYA NOTCH2NLA PRDM14 PRDM6 RBAK SCYL3 SF3B4 SPRY2 TAX1BP1 TCF3 TFIP11 TRAF2 TRIM42 TRIM54 TRIP6 UBC ZNF143 ZNF24 ZNF263 ZNF592
Entrez ID		10256	9747
HPRD ID		11937	13813
Ensembl ID		ENSG00000142675	ENSG00000198420
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	B4DST7 Q9Y4C2
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?
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