RAG1 and HMGB2

Data Source:
HPRD (in vitro)

		RAG1	HMGB2
Description		recombination activating 1	high mobility group box 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	Chromatin Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity	Four-way Junction DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	Apoptosis induced DNA fragmentation
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Rheumatoid arthritis ( 24390342)
Interacting Genes		17 interacting genes: APP DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBC UBE2C UBE2D1 UBE2D2 UBE2H	38 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 TSNAX ZNF428 ZNF622 ZNF668
Entrez ID		5896	3148
HPRD ID		01556	01229
Ensembl ID		ENSG00000166349	ENSG00000164104
Uniprot IDs		P15918	P26583
PDB IDs
Enriched GO Terms of Interacting Partners?
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