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NLRC4 and PYCARD
Data Source:
BioGRID
(two hybrid)
HPRD
(in vitro, in vivo)
NLRC4
PYCARD
Description
NLR family CARD domain containing 4
PYD and CARD domain containing
Image
GO Annotations
Cellular Component
Cytosol
IPAF Inflammasome Complex
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Secretory Granule Lumen
Azurophil Granule Lumen
Neuronal Cell Body
NLRP1 Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Molecular Function
Magnesium Ion Binding
Protein Binding
ATP Binding
Identical Protein Binding
Protein Homodimerization Activity
Endopeptidase Activator Activity
Caspase Binding
Protease Binding
Interleukin-6 Receptor Binding
Protein Binding
Tropomyosin Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Myosin I Binding
Enzyme Binding
Pyrin Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Dimerization Activity
BMP Receptor Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Biological Process
Activation Of Innate Immune Response
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
Positive Regulation Of Protein Processing
Detection Of Bacterium
Positive Regulation Of Interleukin-1 Beta Production
Defense Response To Bacterium
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Homooligomerization
Pyroptosis
Activation Of Cysteine-type Endopeptidase Activity
Myeloid Dendritic Cell Activation
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Myeloid Dendritic Cell Activation Involved In Immune Response
Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Positive Regulation Of Adaptive Immune Response
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
Signal Transduction
Regulation Of Autophagy
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Actin Filament Polymerization
Regulation Of Protein Stability
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interferon-beta Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Macropinocytosis
Innate Immune Response
Positive Regulation Of JNK Cascade
Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Defense Response To Gram-negative Bacterium
Positive Regulation Of T Cell Activation
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Homooligomerization
Defense Response To Virus
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Protein Serine/threonine Kinase Activity
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Activation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of T Cell Migration
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
TP53 Regulates Transcription of Caspase Activators and Caspases
The IPAF inflammasome
The IPAF inflammasome
CLEC7A/inflammasome pathway
Neutrophil degranulation
The NLRP3 inflammasome
The AIM2 inflammasome
Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Inflammatory biomarkers (
24182552
)
Interleukin-18 levels (
27989323
31584380
)
Male-pattern baldness (
28196072
)
Post bronchodilator FEV1 (
26634245
)
Interacting Genes
5 interacting genes:
BCL10
CASP1
NLRP4
NOD2
PYCARD
12 interacting genes:
CASP1
EXOC5
MEFV
NLRC4
NLRP1
NLRP12
NLRP3
POP1
PRKAR1A
PYDC2
SRF
USP50
Entrez ID
58484
29108
HPRD ID
06014
06020
Ensembl ID
ENSG00000091106
ENSG00000103490
Uniprot IDs
Q9NPP4
Q9ULZ3
PDB IDs
6K8J
6MKS
6N1I
1UCP
2KN6
3J63
5H8O
6K99
6KI0
6N1H
Enriched GO Terms of Interacting Partners
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