PYCARD and NLRP3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		PYCARD	NLRP3
Description		PYD and CARD domain containing	NLR family pyrin domain containing 3
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Golgi Membrane Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol NLRP3 Inflammasome Complex
	Molecular Function	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Myosin I Binding Enzyme Binding Pyrin Domain Binding Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Peptidoglycan Binding Sequence-specific DNA Binding
	Biological Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of T Cell Migration Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Response To Organic Cyclic Compound Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection	Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Post bronchodilator FEV1 ( 26634245)	C-reactive protein levels ( 30388399 21300955) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 32888494 27863252) Word reading ( 23738518)
Interacting Genes		12 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF USP50	10 interacting genes: ATP1B3 CARD8 CUL1 FAF1 FBXL2 PGM1 PYCARD STAMBP TRIM31 VDR
Entrez ID		29108	114548
HPRD ID		06020	05915
Ensembl ID		ENSG00000103490	ENSG00000162711
Uniprot IDs		Q9ULZ3	Q96P20
PDB IDs		1UCP 2KN6 3J63 5H8O 6K99 6KI0 6N1H	2NAQ 3QF2 6NPY
Enriched GO Terms of Interacting Partners?
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