NLRC4 and NLRP4

Data Source:
HPRD (in vitro)

		NLRC4	NLRP4
Description		NLR family CARD domain containing 4	NLR family pyrin domain containing 4
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GO Annotations	Cellular Component	Cytosol IPAF Inflammasome Complex	Cytosol
	Molecular Function	Magnesium Ion Binding Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Endopeptidase Activator Activity Caspase Binding	ATP Binding
	Biological Process	Activation Of Innate Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Positive Regulation Of Protein Processing Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptosis Activation Of Cysteine-type Endopeptidase Activity	Inflammatory Response Regulation Of Type I Interferon Production
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases The IPAF inflammasome The IPAF inflammasome	IRF3 mediated activation of type 1 IFN Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Male-pattern baldness ( 28196072)	Plasma anti-thyroglobulin levels ( 29678681)
Interacting Genes		5 interacting genes: BCL10 CASP1 NLRP4 NOD2 PYCARD	2 interacting genes: CHUK NLRC4
Entrez ID		58484	147945
HPRD ID		06014	09619
Ensembl ID		ENSG00000091106	ENSG00000160505
Uniprot IDs		Q9NPP4	B2RCA1 Q96MN2
PDB IDs		6K8J 6MKS 6N1I	4EWI
Enriched GO Terms of Interacting Partners?
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