PTPN9 and SPAG4

Data Source:
BioGRID (two hybrid)

		PTPN9	SPAG4
Description		protein tyrosine phosphatase non-receptor type 9	sperm associated antigen 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Neuron Projection Terminus	Nuclear Envelope Nuclear Inner Membrane Cytoplasm Cytoskeleton Integral Component Of Membrane Motile Cilium Meiotic Nuclear Membrane Microtubule Tethering Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding	Structural Molecule Activity Protein Binding Protein-membrane Adaptor Activity
	Biological Process	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Localization To Plasma Membrane	Nuclear Envelope Organization Spermatogenesis Cell Differentiation
Pathways		Interleukin-37 signaling
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Height ( 25429064 31562340 20189936) Type 2 diabetes ( 30297969)	Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		46 interacting genes: AGTRAP AQP6 ARL13B ARL6IP1 ATP5PF BSND CCR2 CDR1 CERS4 CMTM4 CMTM5 COQ3 CPLX4 CREB3 CREB3L1 DERL2 EBP FAM114A2 FKBP7 GET1 GHR GJB1 GORAB HSD17B11 HSD17B13 LIME1 LMNA MAL2 NSF PBX3 PEX12 PLIN3 REEP6 RTN3 SCAMP1 SLC16A13 SLC30A8 SLC7A1 SPAG4 STX6 SYP TMCO2 TMEM80 TMEM86B TMX2 YIF1A	24 interacting genes: ABHD16A ASGR1 BMP10 CSGALNACT1 ERMP1 GOSR2 IGFBP5 MS4A13 NRM ODF1 PAXIP1 PGA4 PLN PTPN9 RUSF1 SCAMP4 SCD SEC22A SUN5 TMEM187 TMEM60 TNMD TRARG1 TSPO2
Entrez ID		5780	6676
HPRD ID		02864	04330
Ensembl ID		ENSG00000169410	ENSG00000061656
Uniprot IDs		P43378 Q6IQ43	Q9NPE6
PDB IDs		2PA5 4GE2 4GE5 4GE6 4ICZ 6KZQ 6L03
Enriched GO Terms of Interacting Partners?
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