PTPN9 and HSD17B11

Data Source:
BioGRID (two hybrid)

		PTPN9	HSD17B11
Description		protein tyrosine phosphatase non-receptor type 9	hydroxysteroid 17-beta dehydrogenase 11
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Neuron Projection Terminus	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Localization To Plasma Membrane	Estrogen Biosynthetic Process Androgen Catabolic Process
Pathways		Interleukin-37 signaling	Estrogen biosynthesis
Drugs			Aetiocholanolone
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Height ( 25429064 31562340 20189936) Type 2 diabetes ( 30297969)	Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		46 interacting genes: AGTRAP AQP6 ARL13B ARL6IP1 ATP5PF BSND CCR2 CDR1 CERS4 CMTM4 CMTM5 COQ3 CPLX4 CREB3 CREB3L1 DERL2 EBP FAM114A2 FKBP7 GET1 GHR GJB1 GORAB HSD17B11 HSD17B13 LIME1 LMNA MAL2 NSF PBX3 PEX12 PLIN3 REEP6 RTN3 SCAMP1 SLC16A13 SLC30A8 SLC7A1 SPAG4 STX6 SYP TMCO2 TMEM80 TMEM86B TMX2 YIF1A	59 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LNPEP LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SEC22B SERPINE1 SFRP4 SFT2D2 SFXN3 SLC22A18 SLC25A46 SLC30A8 STRIT1 STX5 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VAPA VEZT YIF1A YIPF6
Entrez ID		5780	51170
HPRD ID		02864	10881
Ensembl ID		ENSG00000169410	ENSG00000198189
Uniprot IDs		P43378 Q6IQ43	Q8NBQ5
PDB IDs		2PA5 4GE2 4GE5 4GE6 4ICZ 6KZQ 6L03	1YB1
Enriched GO Terms of Interacting Partners?
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