PTGER4 and PTPRA

Data Source:
BioGRID (two hybrid)

		PTGER4	PTPRA
Description		prostaglandin E receptor 4	protein tyrosine phosphatase receptor type A
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Schaffer Collateral - CA1 Synapse Integral Component Of Synaptic Membrane
	Molecular Function	Prostaglandin E Receptor Activity Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	MAPK Cascade Protein Phosphorylation Protein Dephosphorylation Integrin-mediated Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Modulation Of Chemical Synaptic Transmission Regulation Of Focal Adhesion Assembly
Pathways		Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs		Dinoprostone Misoprostol Limaprost Castor oil Grapiprant
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187 21743469) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 17684544 22936669 22412388 26278503 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697 28445677) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Ulcerative colitis ( 21297633)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	17 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GRB2 HSPB1 KCNA2 LINC00839 MBP PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC
Entrez ID		5734	5786
HPRD ID		03350	01476
Ensembl ID		ENSG00000171522	ENSG00000132670
Uniprot IDs		A0PJF5 P35408	P18433
PDB IDs		5YHL 5YWY	6UZT
Enriched GO Terms of Interacting Partners?
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