PTGER4 and SLC39A8

Data Source:
BioGRID (two hybrid)

		PTGER4	SLC39A8
Description		prostaglandin E receptor 4	solute carrier family 39 member 8
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Organelle Membrane
	Molecular Function	Prostaglandin E Receptor Activity Protein Binding	Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Anion:cation Symporter Activity Selenite:proton Symporter Activity Zinc:bicarbonate Symporter Activity
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein N-linked Glycosylation Arginine Metabolic Process Cobalt Ion Transport Zinc Ion Transport Cellular Cadmium Ion Homeostasis Cellular Zinc Ion Homeostasis Inorganic Anion Transport Bicarbonate Transport Cellular Manganese Ion Homeostasis Extracellular Matrix Organization Regulation Of Membrane Potential Leukocyte Adhesion To Arterial Endothelial Cell Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Iron Ion Import Across Plasma Membrane Cartilage Homeostasis Mitochondrial Manganese Ion Transmembrane Transport
Pathways		Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Zinc influx into cells by the SLC39 gene family
Drugs		Dinoprostone Misoprostol Limaprost Castor oil Grapiprant
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187 21743469) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 17684544 22936669 22412388 26278503 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697 28445677) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Ulcerative colitis ( 21297633)	Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Allergic disease (asthma, hay fever or eczema) ( 29679657) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Blood pressure ( 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 29381148 26961502 25673413 20935630 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878 21909115 28739976 27618452 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil percentage of white cells ( 32888494) Erythrocyte cadmium concentration in never smokers ( 27005419) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hypertension ( 31879980 21909115) Inflammatory bowel disease ( 28067908) Initial pursuit acceleration ( 29064472) Intelligence (MTAG) ( 29326435) LDL cholesterol levels ( 32203549) Left-handedness ( 32989287) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Manganese levels ( 26025379) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Multisite chronic pain ( 31194737) NT-proBNP levels in acute coronary syndrome ( 26908625) Obese vs. thin ( 30677029) Parkinson's disease ( 32201043) Platelet distribution width ( 32888494 27863252) Problematic alcohol use ( 32451486) Red blood cell count ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656) Serum total protein level ( 29403010) Sleep duration (short sleep) ( 30846698) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 21909115 28739976 27618447 27618452 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549 32154731) Voxel-wise structural brain imaging measurements ( 30649180) vWF levels ( 30586737) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	1 interacting genes: PTGER4
Entrez ID		5734	64116
HPRD ID		03350	12286
Ensembl ID		ENSG00000171522	ENSG00000138821
Uniprot IDs		A0PJF5 P35408	A0A024RDG0 Q9C0K1
PDB IDs		5YHL 5YWY
Enriched GO Terms of Interacting Partners?
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