PTPRA and KCNA2

Data Source:
HPRD (in vitro, in vivo)

		PTPRA	KCNA2
Description		protein tyrosine phosphatase receptor type A	potassium voltage-gated channel subfamily A member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Schaffer Collateral - CA1 Synapse Integral Component Of Synaptic Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Lamellipodium Axon Dendrite Lamellipodium Membrane Neuronal Cell Body Membrane Paranodal Junction Presynaptic Membrane Perikaryon Axon Terminus Juxtaparanode Region Of Axon
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Protein Dephosphorylation Integrin-mediated Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Modulation Of Chemical Synaptic Transmission Regulation Of Focal Adhesion Assembly	Potassium Ion Transport Regulation Of Dopamine Secretion Neuronal Action Potential Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade	Voltage gated Potassium channels
Drugs			Enflurane Promethazine Miconazole Dalfampridine
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		17 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GRB2 HSPB1 KCNA2 LINC00839 MBP PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC	16 interacting genes: CAMLG CNTNAP2 CTTN DLG1 DLG4 ETV1 FAM3C KCNA3 KCNA4 KCNA5 KCNAB1 KCNAB2 NEU1 PTK2B PTPRA RHOA
Entrez ID		5786	3737
HPRD ID		01476	01443
Ensembl ID		ENSG00000132670	ENSG00000177301
Uniprot IDs		P18433	P16389
PDB IDs		6UZT
Enriched GO Terms of Interacting Partners?
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