ZMIZ1 and TBC1D4

Data Source:
HPRD (two hybrid)

		ZMIZ1	TBC1D4
Description		zinc finger MIZ-type containing 1	TBC1 domain family member 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytosol Vesicle
	Molecular Function	Transcription Coactivator Activity Zinc Ion Binding Nuclear Receptor Coactivator Activity SMAD Binding	GTPase Activator Activity Protein Binding
	Biological Process	Vasculogenesis In Utero Embryonic Development Heart Morphogenesis Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Vitellogenesis Cell Aging Pyramidal Neuron Migration Androgen Receptor Signaling Pathway Regulation Of Protein Sumoylation Positive Regulation Of T Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin-mediated Maintenance Of Transcription Positive Regulation Of Fibroblast Proliferation Developmental Growth Artery Morphogenesis SMAD Protein Signal Transduction Positive Regulation Of Nucleic Acid-templated Transcription	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 20351715) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 23535729 20453838) Brown vs. black hair color ( 30531825) Celiac disease ( 22057235 20190752 25920553 30572963) Ceramide levels (C24:0) ( 32489964) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cobalt levels ( 26025379) Colorectal cancer ( 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 25489960 28067908 21102463) Crohn's disease and psoriasis ( 22482804) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Height ( 25282103 25429064 23563607 31562340) High density lipoprotein cholesterol levels ( 31928498) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Mean platelet volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 19525953 21833088) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Prostate cancer ( 31562322) Psoriasis ( 25854761 23143594) Psoriasis vulgaris ( 26626624) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) TPE interval (resting) ( 32386560) Triiodothyronine/thyroxine ratio ( 30824882) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 31118516 32499647 30718926 28869590) Urate levels ( 31578528) Vitiligo ( 20526339) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)	Diabetic retinopathy ( 23562823) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		5 interacting genes: AR CACHD1 CNTNAP2 PIAS3 TBC1D4	16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		57178	9882
HPRD ID		12115	18164
Ensembl ID		ENSG00000108175	ENSG00000136111
Uniprot IDs		A0A024QZN6 A0JLS3 Q9ULJ6	A0A3B3IRT3 O60343
PDB IDs		5AIZ	3QYB
Enriched GO Terms of Interacting Partners?
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