PELI1 and CNTROB

Data Source:
BioGRID (two hybrid)

		PELI1	CNTROB
Description		pellino E3 ubiquitin protein ligase 1	centrobin, centriole duplication and spindle assembly protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Kinetochore Cytosol	Centrosome Centriole Cytosol
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Cytokine Production Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of Necroptotic Process Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Centriole Replication Centrosome Separation Regulation Of Cilium Assembly Mitotic Cytokinetic Process
Pathways		Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Allergic dermatitis (nickel) ( 23921680) HOMA-B (corrected for HOMA-IR) ( 30369944) Kawasaki disease ( 21221998)	Refractive error ( 32231278)
Interacting Genes		31 interacting genes: BCL6 BIRC3 BUB1B CLEC17A CNTROB GOSR2 IKBKB INPP5J IRAK1 IRAK2 IRAK4 IRS1 LCN2 LMNA MDM4 RIMS4 RIPK1 RIPK3 SRPK1 SRPK2 TP53 TP63 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14	17 interacting genes: APTX COASY CWF19L2 DAPK1 DUSP29 ELOA EPM2AIP1 LYST MCRS1 PELI1 PNKP RAD23A RSPH14 SYT6 TCEA2 TSHZ2 TTC23
Entrez ID		57162	116840
HPRD ID		17834	13991
Ensembl ID		ENSG00000197329	ENSG00000170037
Uniprot IDs		Q53T26 Q96FA3	Q8N137
PDB IDs
Enriched GO Terms of Interacting Partners?
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