PELI1 and RIMS4

Data Source:
BioGRID (two hybrid)

		PELI1	RIMS4
Description		pellino E3 ubiquitin protein ligase 1	regulating synaptic membrane exocytosis 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Kinetochore Cytosol	Presynaptic Active Zone Synaptic Membrane
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Ion Channel Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Cytokine Production Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of Necroptotic Process Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Neurotransmitter Transport Exocytosis Regulation Of Membrane Potential Regulation Of Synaptic Vesicle Exocytosis
Pathways		Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Allergic dermatitis (nickel) ( 23921680) HOMA-B (corrected for HOMA-IR) ( 30369944) Kawasaki disease ( 21221998)	Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Meat-related diet ( 32066663) Obesity-related traits ( 23251661)
Interacting Genes		31 interacting genes: BCL6 BIRC3 BUB1B CLEC17A CNTROB GOSR2 IKBKB INPP5J IRAK1 IRAK2 IRAK4 IRS1 LCN2 LMNA MDM4 RIMS4 RIPK1 RIPK3 SRPK1 SRPK2 TP53 TP63 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14	4 interacting genes: APP PELI1 SPP1 SRPK1
Entrez ID		57162	140730
HPRD ID		17834	17977
Ensembl ID		ENSG00000197329	ENSG00000101098
Uniprot IDs		Q53T26 Q96FA3	Q9H426
PDB IDs
Enriched GO Terms of Interacting Partners?
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