CNTROB and APTX

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CNTROB	APTX
Description		centrobin, centriole duplication and spindle assembly protein	aprataxin
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding Protein Domain Specific Binding	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding Single-strand Break-containing DNA Binding
	Biological Process	Centriole Replication Centrosome Separation Regulation Of Cilium Assembly Mitotic Cytokinetic Process	Single Strand Break Repair DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases			Coenzyme Q10 deficiency Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS		Refractive error ( 32231278)	Height ( 28552196) Menopause (age at onset) ( 26414677)
Interacting Genes		17 interacting genes: APTX COASY CWF19L2 DAPK1 DUSP29 ELOA EPM2AIP1 LYST MCRS1 PELI1 PNKP RAD23A RSPH14 SYT6 TCEA2 TSHZ2 TTC23	18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639
Entrez ID		116840	54840
HPRD ID		13991	05892
Ensembl ID		ENSG00000170037	ENSG00000137074
Uniprot IDs		Q8N137	Q7Z2E3
PDB IDs			3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT
Enriched GO Terms of Interacting Partners?
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